Improving Neurorepair in Stroke Brain Through Endogenous Neurogenesis-Enhancing Drugs

Cell Transplantation

Original Articles

Barry Hoffer¹  Seongjin Yu²  Yun Wang²  Kuo-Jen Wu²  Jea-Young Lee³ 

[1] Case Western Reserve University, Cleveland, OH, USA;Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli, Taiwan;University of South Florida Morsani College of Medicine, FL, USA;

关键词: cerebral ischemia;    drug treatment;    neurogenesis;    stem cells;    subventricular zone;    brain repair;   

DOI  :  10.1177/0963689717721230

 received in 2017-03-02, accepted in 2017-03-02,  发布年份 2017

来源: Sage Journals

【 摘 要 】

Stroke induces not only cell death but also neurorepair. De novo neurogenesis has been found in the subventricular zone of the adult mammalian brain days after stroke. Most of these newly generated cells die shortly after the insult. Recent studies have shown that pharmacological manipulation can improve the survival of endogenous neuroprogenitor cells and neural regeneration in stroke rats. As these drugs target the endogenous reparative processes that occur days after stroke, they may provide a prolonged window for stroke therapy. Here, we discuss endogenous neurogenesis-enhancing drugs and review the general status of stroke therapeutics in evaluating the field of pharmacotherapy for stroke.

【 授权许可】

CC BY-NC   
© The Author(s) 2017