An Update on Translating Stem Cell Therapy for Stroke from Bench to Bedside

Journal of Clinical Medicine

Travis Dailey¹  Christopher Metcalf¹  Yusef I. Mosley¹  Robert Sullivan²  Kazutaka Shinozuka²  Naoki Tajiri²  Mibel Pabon²  Sandra Acosta²  Yuji Kaneko²  Harry van Loveren² 

[1] Center of Excellence for Aging & Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 12901 Bruce B. Downs Blvd., Tampa, FL 33612, USA;

关键词: stem cells;    stroke;    transplantation;    translational biomedical research;   

DOI  :  10.3390/jcm2040220

来源: mdpi

【 摘 要 】

With a constellation of stem cell sources available, researchers hope to utilize their potential for cellular repair as a therapeutic target for disease. However, many lab-to-clinic translational considerations must be given in determining their efficacy, variables such as the host response, effects on native tissue, and potential for generating tumors. This review will discuss the current knowledge of stem cell research in neurological disease, mainly stroke, with a focus on the benefits, limitations, and clinical potential.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.