Four New Citrinin Derivatives from a Marine-Derived Penicillium sp. Fungal Strain

Molecules

Mei Ling Wang²  Chun Hua Lu¹  Qing Yan Xu²  Si Yang Song²  Zhi Yu Hu² 

[1] Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong 250012, China; E-Mail:;School of Life Sciences, Xiamen University, 422 South Siming Road, Xiamen, Fujian 361005, China; E-Mails:

关键词: citrinin;    Penicillium sp. ML226;    new metabolites;    marine fungus;   

DOI  :  10.3390/molecules18055723

来源: mdpi

【 摘 要 】

Four new citrinin derivatives, including two citrinin dimers and two citrinin monomer derivatives, were isolated and identified from a marine-derived fungal strain Penicillium sp. ML226 along with six known related compounds. Their structures were elucidated by spectroscopic and chemical methods. The new compounds showed modest cytotoxic activity against HepG-2 cell line and weak antimicrobial activity against Staphylococcus aureus.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.