期刊论文详细信息
Marine Drugs
Five New Cytotoxic Metabolites from the Marine Fungus Neosartorya pseudofischeri
Wen-Jian Lan3  Sheng-Jiao Fu1  Meng-Yang Xu3  Wan-Ling Liang3  Chi-Keung Lam2  Guo-Hua Zhong1  Jun Xu3  De-Po Yang3  Hou-Jin Li2 
[1] Lab of Insect Toxicology, South China Agricultural University, Guangzhou 510642, China;School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China;School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China;
关键词: marine fungus;    Neosartorya pseudofischeri;    phenylpyropene;    pyripyropene;    sesquiterpene;    cytotoxic activity;   
DOI  :  10.3390/md14010018
来源: mdpi
PDF
【 摘 要 】

The marine fungus Neosartorya pseudofischeri was isolated from Acanthaster planci from the South China Sea. In a preliminary bioactivity screening, the crude methanol extract of the fungal mycelia showed significant inhibitory activity against the Sf9 cell line from the fall armyworm Spodoptera frugiperda. Five novel compounds, including 5-olefin phenylpyropene A (1), 13-dehydroxylpyripyropene A (4), deacetylsesquiterpene (7), 5-formyl-6-hydroxy-8-isopropyl-2- naphthoic acid (9) and 6,8-dihydroxy-3-((1E,3E)-penta-1,3-dien-1-yl)isochroman-1-one (10), together with eleven known compounds, phenylpyropene A (2) and C (3), pyripyropene A (5), 7-deacetylpyripyropene A (6), (1S,2R,4aR,5R,8R,8aR)-1,8a-dihydroxy-2-acetoxy-3,8-dimethyl-5- (prop-1-en-2-yl)-1,2,4a, 5,6,7,8,8a-octahydronaphthalene (8), isochaetominine C (11), trichodermamide A (12), indolyl-3-acetic acid methyl ester (13), 1-acetyl-β-carboline (14), 1,2,3,4-tetrahydro-6-hydroxyl-2-methyl-l,3,4-trioxopyrazino[l,2-a]-indole (15) and fumiquinazoline F (16), were obtained. The structures of these compounds were determined mainly by MS and NMR data. The absolute configuration of 9 was assigned by the single-crystal X-ray diffraction studies. Compounds 111 and 15 showed significant cytotoxicity against the Sf9 cells from S. frugiperda.

【 授权许可】

CC BY   
© 2016 by the authors; licensee MDPI, Basel, Switzerland.

【 预 览 】
附件列表
Files Size Format View
RO202003190000192ZK.pdf 1586KB PDF download
  文献评价指标  
  下载次数:6次 浏览次数:9次