Spiculisporic Acids B–D, Three New γ-Butenolide Derivatives from a Sea Urchin-Derived Fungus Aspergillus sp. HDf2

Molecules

Rong Wang¹  Tian-Mi Liu¹  Ming-Hui Shen²  Ming-Qiu Yang²  Quan-Ying Feng²  Xian-Ming Tang² 

[1] id="af1-molecules-17-13175">Hainan Provincial Fisheries Research Institute, Haikou 570203, Hainan, Chi

关键词: γ-butenolide derivatives;    spiculisporic acids B–D;    Aspergillus sp.;    marine fungus;   

DOI  :  10.3390/molecules171113175

来源: mdpi

【 摘 要 】

Three new γ-butenolide derivatives 1–3, named spiculisporic acids B–D, were isolated from the culture of Aspergillus sp. HDf2, a marine-derived fungus that resides in the sea urchin, Anthocidaris crassispina. The structures of 1–3 were elucidated on the basis of spectroscopic methods, including MS and 2D NMR techniques. Their in vitro cytotoxic activities against two cell lines (SGC-7901, human gastric adenocarcinoma and SPC-A-1, human lung adenocarcinoma) and inhibitory activities against Staphylococcus aureus ATCC 51650 were investigated.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.