Antibacterial Bisabolane-Type Sesquiterpenoids from the Sponge-Derived Fungus Aspergillus sp.

Marine Drugs

Dan Li²  Ying Xu³  Chang-Lun Shao²  Rui-Yun Yang⁵  Cai-Juan Zheng²  Yi-Yan Chen²  Xiu-Mei Fu²  Pei-Yuan Qian³  Zhi-Gang She⁴  Nicole J. de Voogd¹ 

[1] Netherlands Centre for Biodiversity Naturalis, P.O. box 9517, Leiden 2300 RA, The Netherlands;Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China;KAUST Global Academic Partnership Program, Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China;School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China;Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, Ministry of Education, School of Chemistry & Chemical Engineering, Guangxi Normal University, Guilin 541004, China;

关键词: bisabolane-type sesquiterpenoid;    antibacterial;    sponge-derived fungus;    Aspergillus sp.;   

DOI  :  10.3390/md10010234

来源: mdpi

【 摘 要 】

Four new bisabolane-type sesquiterpenoids, aspergiterpenoid A (1), (−)-sydonol (2), (−)-sydonic acid (3), and (−)-5-(hydroxymethyl)-2-(2′,6′,6′-trimethyltetrahydro-2H- pyran-2-yl)phenol (4) together with one known fungal metabolite (5) were isolated from the fermentation broth of a marine-derived fungus Aspergillus sp., which was isolated from the sponge Xestospongia testudinaria collected from the South China Sea. Four of them (1–4) are optically active compounds. Their structures and absolute configurations were elucidated by using NMR spectroscopic techniques and mass spectrometric analysis, and by comparing their optical rotations with those related known analogues. Compounds 1–5 showed selective antibacterial activity against eight bacterial strains with the MIC (minimum inhibiting concentrations) values between 1.25 and 20.0 µM. The cytotoxic, antifouling, and acetylcholinesterase inhibitory activities of these compounds were also examined.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland