Two New Altenusin/Thiazole Hybrids and a New Benzothiazole Derivative from the Marine Sponge-Derived Fungus Alternaria sp. SCSIOS02F49

Molecules

Yonghong Liu¹  Ruyan Chen²  Yongqi Tian²  Jinhuai Xu²  Jiangping Xu³  Yaping Chen³ 

[1] CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China;College of Biological Science and Technology, Fuzhou University, Fuzhou 350116, China;School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China;

关键词: sponge-derived fungus;    Alternaria sp. SCSIOS02F49;    altenusin/thiazole hybrids;    benzothiazole derivative;   

DOI  :  10.3390/molecules23112844

来源: DOAJ

【 摘 要 】

Two novel altenusin-thiazole hybrids named altenusinoides A and B (1 and 2), a new benzothiazole derivative (3), and three known altenusin derivatives (4⁻6) have been obtained from the solid culture of the marine sponge-derived fungal strain, Alternaria sp. SCSIOS02F49. The structures of these new compounds were characterized by NMR, HRESIMS, and X-ray single crystal analysis. Compounds 1 and 2 possess an unusual altenusin-thiazole-fused skeleton core (6/6/5), and compound 3 represents the first benzothiazole derivative from fungi. Compounds 4 and 5 showed significant DPPH free-radical-scavenging activities with the prominent IC₅₀ values of 10.7 ± 0.09 μM and 100.6 ± 0.025 μM, respectively. Additionally, compound 5 exhibited COX-2 inhibitory activity with an IC₅₀ value of 9.5 ± 0.08 μM.

【 授权许可】

Unknown