Two New Chiratane-Type Triterpenoids from Swertia kouitchensis

Molecules

Luo-Sheng Wan³  Ting-Ting Liu¹  Xiao-Jun Lin²  Qiu-Xia Min³ 

[1] The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China;Shantou Institute for Drug Control, Shantou 515041, China;Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

关键词: Swertia kouitchensis;    diabetes;    chiratane;    triterpenoid;    α-glucosidase;   

DOI  :  10.3390/molecules18078518

来源: mdpi

【 摘 要 】

Two rare new chiratane-type triterpenoids, kouitchenoids A and B (1, 2), together with oleanolic acid (3) and ursolic acid (4), were isolated from ethanol extract of Swertia kouitchensis. The new structures were determined by the analysis of MS and NMR data. In addition, compounds 1–4 showed moderate inhibitory activity against the α-glucosidase (with IC₅₀ values ranging from 1,812 to 2,027 μM).

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.