A New Saponin from Tea Seed Pomace (Camellia oleifera Abel) and Its Protective Effect on PC12 Cells

Molecules

Xin-Fu Zhang¹  Ying-Ying Han¹  Guan-Hu Bao¹  Tie-Jun Ling¹  Liang Zhang¹  Li-Ping Gao¹ 

[1] ¹Key Laboratory of Tea Biochemistry & Biotechnology, Ministry of Education and Ministry of Agriculture, Anhui Agricultural University, Hefei 230036, China ²College of Horticulture, Qingdao Agricultural University, Qingdao 266109, China ³School of Life Science, Anhui Agricultural University, Hefei 230036, China

关键词: Camellia oleifera;    tea seed pomace;    triterpenoid;    saponin;    PC12 cell;   

DOI  :  10.3390/molecules171011721

来源: mdpi

【 摘 要 】

A new triterpenoid saponin, oleiferasaponin A₁, was isolated from tea seed pomace (Camellia oleifera Abel). The structure of oleiferasaponin A₁ was elucidated on the basis of chemical and physicochemical evidence and was found to be 22-O-cis-2-hexenoyl-A₁-barrigenol 3-O-[β-D-galactopyranosyl(1→2)] [β-D-glucopyranosyl(1→2)-α-L-arabinopyranosyl(1→3)]-β-D-glucopyranosiduronic acid. PC12 cells injured with H₂O₂ were used as the model to test the protective effects of oleiferasaponin A₁. The results indicated that oleiferasaponin A₁ can potentially prevent the H₂O₂-induced cell death of PC12 cells.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.