Molecules | |
Design and Synthesis of Arylthiophene-2-Carbaldehydes via Suzuki-Miyaura Reactions and Their Biological Evaluation | |
Shaukat Ali4  Nasir Rasool4  Aman Ullah1  Faiz-ul-Hassan Nasim3  Asma Yaqoob3  Muhammad Zubair4  Umer Rashid2  | |
[1] Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB T6G2P5, Canada;Institute of Advanced Technology, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia; E-Mail:;Department of Chemistry, Islamia University of Bahawalpur, Bahawalpur 63000, Pakistan; E-Mails:;Department of Chemistry, Government College University, Faisalabad 38000, Pakistan;E-Mails: | |
关键词: thiophene; Pd (0) catalyzed Suzuki coupling; antibacterial; heamolytic; antiurease; antioxidant; activities; | |
DOI : 10.3390/molecules181214711 | |
来源: mdpi | |
【 摘 要 】
A series of various novel 4-arylthiophene-2-carbaldehyde compounds were synthesized in moderate to excellent yields via Suzuki-Miyaura cross-coupling with different arylboronic pinacol esters/acids. The synthesized products were screened for their antibacterial, haemolytic, antiurease, and nitric oxide (NO) scavenging capabilities and interestingly, almost all products turned out to have good activities. 3-(5-Formyl-thiophene-3-yl)-5-(trifloromethyl)benzonitrile (
【 授权许可】
CC BY
© 2013 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
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RO202003190031051ZK.pdf | 351KB | download |