Chemical Composition, Antibacterial and Antifungal Activities of Anthocleista vogelii Planch Root Bark Extracts

8th International Biotechnology Conference, Exhibition and Workshop

Anyanwu, P.I.^1 ; Tarfa, F.D.^2 ; Shamaki, D.E.^3 ; Anyanwu, G.O.^3

Department of Community Health and Wellbeing, University of Chester, Chester, United Kingdom^1

Department of Medicinal Chemistry and Quality Control, National Institute for Pharmaceutical Research and Development (NIPRD), Idu Industrial Area, Abuja, Nigeria^2

Department of Biochemistry, Bingham University, Karu, Nasarawa State, Nigeria^3

关键词: Anthocleista vogelii;    Anti-fungal;    antibacterial;    GCMS;    LCMS;    Terpenoids;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/210/1/012006/pdf
DOI  :  10.1088/1755-1315/210/1/012006

来源: IOP

【 摘 要 】

This study sought to investigate the chemical composition, antibacterial and antifungal activities of ethanol extract and fractions of the root bark of Anthocleista vogelii Planch. The GCMS analysis of the n-hexane fraction (nHF) of A. vogelii revealed the presence of 12 volatile compounds. While the classes of compounds profiled in terpenoid rich fraction (TRF) using LCMS were majorly terpenoids (tarennoside, 3-Hydroxybenzaldehyde, 12-hydroxyjasmonic acid, 5-megastigmen-7-yne-3,9-diol 9-glucoside, gibberellin A2 O-beta-D-glucoside, 15-Acetoxyscirpene-3,4-diol 4-O-a-D-glucopyranoside), organic/carboxylic acids and fatty acids. The results revealed good antibacterial activity of ethanol extract (EEx) against S. aureus at MIC = 2 mg/mL, but moderate activity by TRF (MIC = 8 mg/mL) although, the TRF had better antibacterial activity than EEX against E. coli (MIC = 8 mg/mL) and S. paratyphi (MIC = 8 mg/mL). The TRF had similar antifungal activity with EEX against T. rubrum (MIC = 4 mg/mL) and T. mentagrophytes (MIC = 8 mg/mL), but displayed better activity against C. albicans (MIC = 4 mg/mL). The nHF showed no antibacterial or antifungal activities. The antimicrobial activities of extract (EEX) and fraction (TRF) of A. vogelii root back validates its use in traditional medicine for treatment of typhoid, urinary tract infection, food poisoning, diarrhea, stomach aches and skin diseases.