New Thiophene and Flavonoid from Tagetes minuta Leaves Growing in Saudi Arabia

Molecules

Nawal M. Al-Musayeib¹  Gamal A. Mohamed³  Sabrin R. M. Ibrahim² 

[1]Department of Pharmacognosy, Faculty of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia

[2]Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt

[3] E-Mail:

[4]Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt

[5] E-Mail:

关键词: Tagetes minuta;    Asteraceae;    thiophene;    quercetagetin;    antioxidant;    antimicrobial;    antileishmanial;    antimalarial;   

DOI  :  10.3390/molecules19032819

来源: mdpi

【 摘 要 】

Phytochemical investigation of the methanolic extract of Tagetes minuta L. (Asteraceae) leaves resulted in the isolation and identification of two new compounds: 5-methyl-2,2',5',2'',5'',2''',5''',2''''-quinquethiophene (1) and quercetagetin-6-O-(6-O-caffeoyl-β-d-glucopyranoside) (9), in addition to seven known compounds: quercetin-3,6-dimethyl ether (2), quercetin-3-methyl ether (3), quercetin (4), axillarin-7-O-β-d-glucopyranoside (5), quercetagetin-3,7-dimethoxy-6-O-β-d-glucopyranoside (6), quercetagetin-7-methoxy-6-O-β-d-glucopyranoside (7), and quercetagetin-6-O-β-d-glucopyranoside (8). The compounds were identified by UV, IR, 1D, 2D NMR, and HRESIMS spectral data. They showed significant antioxidant activity, comparable with that of propyl gallate. Compounds 8 and 3 showed weak to moderate antileishmanial and antimalarial activities, with IC₅₀ values of 31.0 μg/mL and 4.37 μg/mL, respectively.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.