Journal of Personalized Medicine | |
Design and Implementation of a Randomized Controlled Trial of Genomic Counseling for Patients with Chronic Disease | |
Kevin Sweet2  Erynn S. Gordon4  Amy C. Sturm2  Tara J. Schmidlen4  Kandamurugu Manickam2  Amanda Ewart Toland2  Margaret A. Keller4  Catharine B. Stack4  J. Felipe Garc-Espa༚4  Mark Bellafante4  Neeraj Tayal1  Peter Embi5  Philip Binkley3  Ray E. Hershberger2  Wolfgang Sadee6  Michael Christman4  | |
[1] Department of Internal Medicine, Ohio State University College of Medicine, Columbus, OH 43420, USA; E-Mail:;Division of Human Genetics, Ohio State University Wexner Medical Center, Columbus, OH 43420, USA; E-Mails:;Division of Cardiovascular Medicine, Ohio State University College of Medicine, Columbus, OH 43420, USA; E-Mail:;Coriell Institute for Medical Research, 403 Haddon Avenue, Camden, NJ 08103, USA; E-Mails:;Department of Bioinformatics, Ohio State University College of Medicine, Columbus, OH 43420, USA; E-Mail:;Program in Pharmacogenomics, Department of Pharmacology, The Ohio State University College of Medicine, Columbus, OH 43420, USA; E-Mail: | |
关键词: implementation; genomics; medicine; randomized; patients; counseling; actionable; risk perception; pharmacogenomics; | |
DOI : 10.3390/jpm4010001 | |
来源: mdpi | |
【 摘 要 】
We describe the development and implementation of a randomized controlled trial to investigate the impact of genomic counseling on a cohort of patients with heart failure (HF) or hypertension (HTN), managed at a large academic medical center, the Ohio State University Wexner Medical Center (OSUWMC). Our study is built upon the existing Coriell Personalized Medicine Collaborative (CPMC®). OSUWMC patient participants with chronic disease (CD) receive eight actionable complex disease and one pharmacogenomic test report through the CPMC® web portal. Participants are randomized to either the in-person post-test genomic counseling—active arm,
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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RO202003190030100ZK.pdf | 1855KB | download |