Molecules | |
Cinchona Alkaloid Derivative-Catalyzed Enantioselective Synthesis via a Mannich-Type Reaction and Antifungal Activity of β-Amino Esters Bearing Benzoheterocycle Moieties | |
Han Xiao1  Fang Wu1  Li Shi1  Zhiwei Chen1  Shihu Su1  Chenghao Tang1  Hongtao Wang1  Zhining Li1  Meichuan Li1  | |
[1] Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, China; E-Mails: | |
关键词: β-amino acid ester; antifungal activity; benzoheterocycle; enantioselective synthesis; | |
DOI : 10.3390/molecules19043955 | |
来源: mdpi | |
【 摘 要 】
An efficient synthesis of highly functionalized chiral β-amino ester derivatives containing benzothiophene and benzothiazole moieties is developed by a Mannich-type reaction using a cinchona alkaloid-derived thiourea catalyst. The desired products were obtained in good yields and high enantioselectivities (~86% yield, >99% ee) using to the optimized reaction conditions. The synthesized compounds were characterized by 1H-NMR, 13C-NMR, IR, and HREI-MS analyses. The bioassays identified that compound
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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RO202003190027636ZK.pdf | 359KB | download |