Ultrasound-assisted synthesis of 1-N-β-D-glucopyranosyl-1H-1,2,3-triazole benzoheterocycles and their anti-inflammatory activities

Journal of the Brazilian Chemical Society

Universidade Federal Rural de Pernambuco, Recife, Brazil¹  Silva, Gilson B. da¹  Oliveira, Ronaldo N. de¹  Guimarães, Bruna M.¹  Assis, Shalom P. O.¹  Lima, Vera L. M.¹ 

关键词: triazole;    click chemistry;    ultrasound;    anti-inflammatory activity;    carbohydrate;    benzoheterocycle;   

DOI  :  10.5935/0103-5053.20130117

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

In this work, the preparation of various glucosyl triazoles from a reaction between 2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl azide and terminal alkynes was developed in moderate to excellent yields (63-99%). Ultrasound energy was applied at each step of the reaction to increase chemical reactivity. In addition, the compounds conjugated with benzoheterocycles moieties revealed potent anti-inflammatory activity.

【 授权许可】

Unknown