Chemical Architecture and Applications of Nucleic Acid Derivatives Containing 1,2,3-Triazole Functionalities Synthesized via Click Chemistry

Molecules

Tim Efthymiou¹  Wei Gong¹ 

[1] id="af1-molecules-17-12665">Faculty of Science, University of Ontario Institute of Technology, 2000 Simcoe St N, Oshawa, ON L1H 7K4, Cana

关键词: click chemistry;    triazole;    CuAAC;    nucleic acids;    oligonucleotides;    bioconjugation;    copper-catalyzed;    Huisgen dipolar cycloaddition;    azide;    alkyne;   

DOI  :  10.3390/molecules171112665

来源: mdpi

【 摘 要 】

There is considerable attention directed at chemically modifying nucleic acids with robust functional groups in order to alter their properties. Since the breakthrough of copper-assisted azide-alkyne cycloadditions (CuAAC), there have been several reports describing the synthesis and properties of novel triazole-modified nucleic acid derivatives for potential downstream DNA- and RNA-based applications. This review will focus on highlighting representative novel nucleic acid molecular structures that have been synthesized via the “click” azide-alkyne cycloaddition. Many of these derivatives show compatibility for various applications that involve enzymatic transformation, nucleic acid hybridization, molecular tagging and purification, and gene silencing. The details of these applications are discussed. In conclusion, the future of nucleic acid analogues functionalized with triazoles is promising.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.