Ultrasound-assisted synthesis of 1-N-β-D-glucopyranosyl-1H-1,2,3-triazole benzoheterocycles and their anti-inflammatory activities

Journal of the Brazilian Chemical Society

Gilson B. Da Silva²  Bruna M. Guimarães²  Shalom P. O. Assis¹  Vera L. M. Lima¹  Ronaldo N. De Oliveira² 

[1] ,Universidade Federal Rural de Pernambuco Departamento de Ciências Moleculares Recife PE ,Brazil

关键词: triazole;    click chemistry;    ultrasound;    anti-inflammatory activity;    carbohydrate;    benzoheterocycle;   

DOI  :  10.5935/0103-5053.20130117

来源: SciELO

【 摘 要 】

In this work, the preparation of various glucosyl triazoles from a reaction between 2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl azide and terminal alkynes was developed in moderate to excellent yields (63-99%). Ultrasound energy was applied at each step of the reaction to increase chemical reactivity. In addition, the compounds conjugated with benzoheterocycles moieties revealed potent anti-inflammatory activity.

【 授权许可】

CC BY   
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