Synthesis and Anti-TMV Activity of Dialkyl/dibenzyl 2-((6-Substituted-benzo[d]thiazol-2-ylamino)(benzofuran-2-yl)methyl) Malonates

Molecules

Han Xiao¹  Pengcheng Zheng¹  Chenghao Tang¹  Ying Xie¹  Fang Wu¹  Jie Song¹  Jun Zhao¹  Zhining Li¹ 

[1] Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, China; E-Mails:

关键词: benzofuran;    benzothiazole;    β-amino acid ester;    anti-TMV activity;   

DOI  :  10.3390/molecules181113623

来源: mdpi

【 摘 要 】

Starting from benzofuran-2-methanal, 6-substituted benzothiazole-2-amines and malonic esters, sixteen title compounds were designed and synthesized seeking to introduce anti-TMV activity. The structures of the newly synthesized compounds were confirmed by ¹H-NMR, ¹³C-NMR, IR spectra, and MS (HREI) analysis. The bioassays identified some of these new compounds as having moderate to good anti-TMV activity. The compounds 5i and 5m have good antiviral activity against TMV with a curative rate of 52.23% and 54.41%, respectively, at a concentration of 0.5 mg/mL.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.