Synthesis of Riboflavines, Quinoxalinones and Benzodiazepines through Chemoselective Flow Based Hydrogenations

Molecules

Marcus Baumann²  Ian R. Baxendale²  Christian H. Hornung¹  Steven V. Ley¹  Maria Victoria Rojo¹ 

[1] Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK;Department of Chemistry, University of Durham, South Road, Durham DH1 3LE, UK

关键词: flow chemistry;    hydrogenation;    riboflavine;    benzodiazepine;    micro reactor;   

DOI  :  10.3390/molecules19079736

来源: mdpi

【 摘 要 】

Robust chemical routes towards valuable bioactive entities such as riboflavines, quinoxalinones and benzodiazepines are described. These make use of modern flow hydrogenation protocols enabling the chemoselective reduction of nitro group containing building blocks in order to rapidly generate the desired amine intermediates in situ. In order to exploit the benefits of continuous processing the individual steps were transformed into a telescoped flow process delivering selected benzodiazepine products on scales of 50 mmol and 120 mmol respectively.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.