MiRiad Roles for MicroRNAs in Cardiac Development and Regeneration

Cells

Ashley M. Fuller¹ 

[1] Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA; E-Mail:

关键词: miRNA;    cardiovascular development;    cardiac regeneration;    direct cell reprogramming;    differentiation;    myosin isoform switching;   

DOI  :  10.3390/cells3030724

来源: mdpi

【 摘 要 】

Cardiac development is an exquisitely regulated process that is sensitive to perturbations in transcriptional activity and gene dosage. Accordingly, congenital heart abnormalities are prevalent worldwide, and are estimated to occur in approximately 1% of live births. Recently, small non-coding RNAs, known as microRNAs, have emerged as critical components of the cardiogenic regulatory network, and have been shown to play numerous roles in the growth, differentiation, and morphogenesis of the developing heart. Moreover, the importance of miRNA function in cardiac development has facilitated the identification of prospective therapeutic targets for patients with congenital and acquired cardiac diseases. Here, we discuss findings attesting to the critical role of miRNAs in cardiogenesis and cardiac regeneration, and present evidence regarding the therapeutic potential of miRNAs for cardiovascular diseases.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.