Small Engine, Big Power: MicroRNAs as Regulators of Cardiac Diseases and Regeneration

International Journal of Molecular Sciences

Darukeshwara Joladarashi¹  Rajarajan Amirthalingam Thandavarayan¹  Sahana Suresh Babu¹ 

[1] Department of Cardiovascular Sciences, Centre for Cardiovascular Regeneration, Houston Methodist Research Institute, Houston, TX 77030, USA;

关键词: miRNA;    cardiac development;    cardiovascular diseases;    hypertrophy;    fibrosis;    arrhythmia;    cardiac regeneration;    stem cells;   

DOI  :  10.3390/ijms150915891

来源: mdpi

【 摘 要 】

Cardiac diseases are the predominant cause of human mortality in the United States and around the world. MicroRNAs (miRNAs) are small non-coding RNAs that have been shown to modulate a wide range of biological functions under various pathophysiological conditions. miRNAs alter target expression by post-transcriptional regulation of gene expression. Numerous studies have implicated specific miRNAs in cardiovascular development, pathology, regeneration and repair. These observations suggest that miRNAs are potential therapeutic targets to prevent or treat cardiovascular diseases. This review focuses on the emerging role of miRNAs in cardiac development, pathogenesis of cardiovascular diseases, cardiac regeneration and stem cell-mediated cardiac repair. We also discuss the novel diagnostic and therapeutic potential of these miRNAs and their targets in patients with cardiac diseases.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.