Effect of Outflow Tract Banding on Embryonic Cardiac Hemodynamics

Journal of Cardiovascular Development and Disease

Venkat Keshav Chivukula¹  Sevan Goenezen⁴  Aiping Liu⁵  Sandra Rugonyi³  Robert E. Poelmann² 

[1] Department of Mechanical Engineering, University of Washington, Stevens Way, Box 352600, Seattle, WA 98195, USA;;Department of Mechanical Engineering, University of Washington, Stevens Way, Box 352600, Seattle, WA 98195, USADepartment of Biomedical Engineering, Oregon Health & Science University, 3303 SW Bond Ave. M/C CH13B, Portland, OR 97239, USA;Department of Mechanical Engineering, Texas A&M University, College Station, TX 77840, USA;Department of Biomedical Engineering, University of Wisconsin-Madison, 1550 Engineering Drive, ECB 2145, Madison, WI 53706, USA;

关键词: chicken embryonic heart;    outflow tract;    computational fluid dynamics (CFD);    congenital heart disease;    cardiovascular development;    hemodynamics;    cardiac development;   

DOI  :  10.3390/jcdd3010001

来源: mdpi

【 摘 要 】

We analyzed heart wall motion and blood flow dynamics in chicken embryos using in vivo optical coherence tomography (OCT) imaging and computational fluid dynamics (CFD) embryo-specific modeling. We focused on the heart outflow tract (OFT) region of day 3 embryos, and compared normal (control) conditions to conditions after performing an OFT banding intervention, which alters hemodynamics in the embryonic heart and vasculature. We found that hemodynamics and cardiac wall motion in the OFT are affected by banding in ways that might not be intuitive a priori. In addition to the expected increase in ventricular blood pressure, and increase blood flow velocity and, thus, wall shear stress (WSS) at the band site, the characteristic peristaltic-like motion of the OFT was altered, further affecting flow and WSS. Myocardial contractility, however, was affected only close to the band site due to the physical restriction on wall motion imposed by the band. WSS were heterogeneously distributed in both normal and banded OFTs. Our results show how banding affects cardiac mechanics and can lead, in the future, to a better understanding of mechanisms by which altered blood flow conditions affect cardiac development leading to congenital heart disease.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.