Gd-Complexes of New Arylpiperazinyl Conjugates of DTPA-Bis(amides): Synthesis, Characterization and Magnetic Relaxation Properties

Molecules

Abdullah O. Ba-Salem²  Nisar Ullah²  M. Nasiruzzaman Shaikh³  Mohamed Faiz⁴  Zaheer Ul-Haq¹ 

[1] Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan; E-Mail:;Chemistry Department, King Fahd University of Petroleum and Minerals, Dhahran-31261, Saudi Arabia; E-Mail:;Center of Research Excellence in Nanotechnology, King Fahd University of Petroleum and Minerals, Dhahran-31261, Saudi Arabia;Physics Department, King Fahd University of Petroleum and Minerals, Dhahran-31261, Saudi Arabia; E-Mail:

关键词: DTPA-bis(amide);    arylpiperazine;    Gd(III)-complexes;    MRI contrast agents;    relaxivity;    magneto-pharmaceuticals;   

DOI  :  10.3390/molecules20057807

来源: mdpi

【 摘 要 】

Two new DTPA-bis(amide) based ligands conjugated with the arylpiperazinyl moiety were synthesized and subsequently transformed into their corresponding Gd(III) complexes 1 and 2 of the type [Gd(L)H₂O] nH₂O. The relaxivity (R₁) of these complexes was measured, which turned out to be comparable with that of Omniscan^®, a commercially available MRI contrast agent. The cytotoxicity studies of these complexes indicated that they are non-toxic, which reveals their potential and physiological suitability as MRI contrast agents. All the synthesized ligands and complexes were characterized with the aid of analytical and spectroscopic methods, including elemental analysis, ¹H-NMR, FT-IR, XPS and fast atom bombardment (FAB) mass spectrometry.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.