Preclinical animal acute toxicity studies of new developed MRI contrast agent based on gadolinium

International Scientific Conference on "Radiation-Thermal Effects and Processes in Inorganic Materials"

材料科学;物理学

Nam, I.F.^1,2 ; Zhuk, V.V.^1

MedContrastSynthesis LLC, Tomsk, Russia^1

National Research Tomsk Politechnic University, Tomsk, Russia^2

关键词: Acute toxicity;    Acute toxicity test;    Adverse effect;    Clinical symptoms;    Maximum tolerated dose;    MRI contrast agents;    Preclinical studies;    Sprague-Dawley rats;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/81/1/012092/pdf
DOI  :  10.1088/1757-899X/81/1/012092

学科分类：材料科学（综合）

来源: IOP

【 摘 要 】

Acute toxicity test of new developed MRI contrast agent based on disodium salt of gadopentetic acid complex were carried out on Mus musculus and Sprague Dawley rats according to guidelines of preclinical studies [1]. Groups of six animals each were selected for experiment. Death and clinical symptoms of animals were recorded during 14 days. As a result the maximum tolerated dose (MTD) for female mice is 2.8 mM/kg of body weight, male mice - 1.4 mM/kg, female rats - 2.8 mM/kg, male rats - 5.6 mM/kg of body weight. No Observed Adverse Effect Dose (NOAEL) for female mice is 1.4 mM/kg, male mice - 0.7 mM/kg, male and female rats - 0.7 mM/kg. According to experimental data new developed MRI contrast agent based on Gd-DTPA complex is low-toxic.