Gd-complexes of DTPA-bis(amide) Conjugates of Phosphonated Tranexamic Esters as MRI Contrast Agents

Bulletin of the Korean chemical society

Gang Ho Lee¹  Yongmin Chang¹  Hee Kyung Kim¹  Mehul A. Patel¹  Tae Jeong Kim¹ 

关键词: DTPA-bis(amide);    MRI CAs;    Phosphonates;    Tranexamate;    Gd-complexes;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

The syntheses of DTPA-bis(amide) conjugates of phosphonated cyclohexane moieties (5a-d) and their Gd(III) complexes of the type [Gd(L)(H2O)]·nH2O (6a-d; L = 5a-d) are described. All new compounds have been characterized by microanalysis and spectroscopic techniques. High r1 relaxivities of aqueous solutions of 6a-d are observed to be in the range of 10.7-18.3 mM−1sec−1, which compare much better than that of Omniscan® (r1 = 3.90 mM−1sec−1).

【 授权许可】

Unknown