Determination of Correlation Times of New Paramagnetic Gadolinium MR Contrast Agents by EPR and 17O NMR

Bulletin of the Korean chemical society

Gang Ho Lee¹  Yongmin Chang¹  Hee Kyung Kim¹  Tae Jeong Kim¹ 

关键词: MRI CA;    Gadolinium chelate;    Tranexamate;    Correlation times;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

The work describes EPR and ¹⁷O NMR measurements followed by theoretical calculation of the rotational correlation time (ンR), the water residence time (ンm), and the longitudinal electronic spin relaxation time (T_1e) for two new gadolinium complexes 1 and 2 of the type [Gd(L)(H₂O)] (L = tranexamic esters) in order to investigate their efficiency as a paramagnetic contrast agent (PCA). Of three correlation times, ンR plays a major and predominant role to the unusually high relaxivity of 1 and 2 as compared with that of clinically approved MR CAs such as [Gd(DTPA)(H₂O)]^2- (Magnevist^?), [Gd(DTPA?BMA)(H₂O)] (Omniscan^?), and [Gd(DOTA)(H₂O)]^- (Dotarem^?). The presence of bulky tranexamic ester in the ligand seems to be responsible for the conformational rigidity, which in turn causes such great an increase in ンR.

【 授权许可】

Unknown