Gd-Complexes of DTPA-bis(amides) Functionalized by Pyridine and Picolinamide: Synthesis, Thermodynamic Stability, and Relaxivity Properties

Bulletin of the Korean chemical society

Ji-Ae Park¹  ¢Ó¹  Nasiruzzaman Sk¹  Tae-Jeong Kim¹  Yongmin Chang¹  Md.¹ 

关键词: MRI CA;    Gd(DTPA-bisamide);    Pyridine;    Picolinamide;    T1 relaxivity;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

A series of DTPA-bis(amides) functionalized by pyridine (1a-c) and N-phenylpicolinamide) (1d-e) and their Gd(III)-complexes of the type [Gd(1)(H₂O)]·xH2O (2a-e) were prepared and characterized by analytical and spectroscopic techniques. Potentiality of 2a-e as contrast agents for magnetic resonance imaging (MRI CA) was investigated by measuring relevant physicochemical properties and relaxivities and compared with [Gd(DTPA-BMA)(H₂O)] (DTPA-BMA=N,N``-di(methylcarbamoylmethyl)diethylenetriamine-N,N`,N``-triacetate) (Omniscan^R). The R1 relaxivities of aqueous solutions of 2a-c are in the range of 3.33 -5.02 mM^?1sec^?1, which are comparable with those of Omniscan^R (r1=4.58 mM^?1sec^?1). Complexes 2d-e, insoluble in water, exhibit relatively higher R1 values (8.1- 8.3 mM?1sec^?1) in HP-�?-CD solutions.

【 授权许可】

Unknown