A new efficient synthesis of pyrazoles from hydrazonoyl halides and β-oxophosphonates

TETRAHEDRON LETTERS

卷:55

Article

Sun, Aixue¹  Ye, Jia-Hai¹  Yu, Haitao²  Zhang, Wenchao¹  Wang, Xiaolong² 

[1] Nanjing Univ Sci & Technol, Sch Chem Engn, Nanjing 210094, Jiangsu, Peoples R China

[2] Nanjing Univ Chinese Med, Coll Pharm, Nanjing 210046, Jiangsu, Peoples R China

关键词: Pyrazoles;    Phosphonates;    Hydrazonoyl halides;    Heterocycles;    Regioselectivity;   

DOI  :  10.1016/j.tetlet.2013.12.045

来源: Elsevier

【 摘 要 】

A new practical and efficient synthesis of 1,3,5-trisubstituted pyrazoles has been developed by reacting of hydrazonoyl halides with beta-oxophosphonates under mild conditions in good yields with excellent regioselectivity. This process employs an addition-elimination sequence. Wide scope, functional group compatibility has been established. (C) 2013 Elsevier Ltd. All rights reserved.

【 授权许可】

Free