Synthesis and Physicochemical Characterization of the Impurities of Pemetrexed Disodium, an Anticancer Drug

Molecules

Olga Michalak¹  Mariusz M. Gruza¹  Anna Witkowska¹  Iwona Bujak¹  Piotr Cmoch¹ 

[1] Pharmaceutical Research Institute, 8 Rydygiera Street, 01-793 Warsaw, Poland; E-Mails:

关键词: pemetrexed;    impurities;    NMR;    diastereoisomers;   

DOI  :  10.3390/molecules200610004

来源: mdpi

【 摘 要 】

A physicochemical characterization of the process-related impurities associated with the synthesis of pemetrexed disodium was performed. The possibility of pemetrexed impurities forming has been mentioned in literature, but no study on their structure has been published yet. This paper describes the development of the synthesis methods for these compounds and discusses their structure elucidation on the basis of two-dimensional NMR experiments and MS data. The identification of these impurities should be useful for the quality control during the production of the pemetrexed disodium salt.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.