2-(tert-Butyl)-4-phenyloxetane

Molbank

Simona Summa¹  Filippo Maria Perna¹  Vito Capriati¹  Paola Vitale¹ 

[1] Dipartimento di Farmacia-Scienze del Farmaco, Università di Bari “A. Moro”, Consorzio C.I.N.M.P.I.S., Via E. Orabona 4, I-70125 Bari, Italy;

关键词: oxetanes;    diols;    diastereoisomers;    cyclization reactions;    NMR;    heterocycles;   

DOI  :  10.3390/M930

来源: DOAJ

【 摘 要 】

The two geometric isomers of 2-(tert-butyl)-4-phenyloxetane have, for the first time, been prepared starting from the commercially available 4,4-dimethyl-1-phenylpentane-1,3-dione. The latter was reduced with NaBH4 to give a mixture of diastereomeric syn and anti diols which were then stereospecifically cyclized into the corresponding oxetanes with an overall yield for the two steps of 69.6%. The newly synthesized stereoisomeric four-membered oxygenated heterocycles were separated by column chromatography on silica gel and fully spectroscopically characterized.

【 授权许可】

Unknown