Bohlmann-Rahtz Cyclodehydration of Aminodienones to Pyridines Using N-Iodosuccinimide

Molecules

Mark C. Bagley¹ 

[1] School of Chemistry, Main Building, Cardiff University, Park Place, Cardiff, CF10 3AT, UK

关键词: Bohlmann-Rahtz synthesis;    cyclization reactions;    heterocycles;    Lewis acids;    pyridines;   

DOI  :  10.3390/molecules15053211

来源: mdpi

【 摘 要 】

Cyclodehydration of Bohlmann-Rahtz aminodienone intermediates using N-iodosuccinimide as a Lewis acid proceeds at low temperature under very mild conditions to give the corresponding 2,3,6-trisubstituted pyridines in high yield and with total regiocontrol.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.