Biodegradable Materials for Bone Repair and Tissue Engineering Applications

Materials

Zeeshan Sheikh⁴  Shariq Najeeb¹  Zohaib Khurshid³  Vivek Verma⁶  Haroon Rashid²  Michael Glogauer⁵ 

[1] School of Clinical Dentistry, University of Sheffield, Sheffield S10 2TN, UK; E-Mail:;College of Dentistry, Division of Prosthodontics, Ziauddin University, 4/B, Clifton, Karachi 7550, Pakistan; E-Mail:;School of Materials and Metallurgy, University of Birmingham, Birmingham B15 2TT, UK; E-Mail:;Faculty of Dentistry, Matrix Dynamics Group, University of Toronto, 150 College Street, Toronto, ON M5S 3E2, Canada;Matrix Dynamics Group, Faculty of Dentistry, University of Toronto, 150 College Street, Toronto, ON M5S 3E2, Canada; E-Mail:;Faculty of Dentistry, Division of Biomedical Sciences, McGill University, 2001 McGill College Avenue, Montreal, QC H3A 1G1, Canada; E-Mail:

关键词: biomaterials;    biodegradable materials;    bone regeneration;    bone repair;    tissue engineering;   

DOI  :  10.3390/ma8095273

来源: mdpi

【 摘 要 】

This review discusses and summarizes the recent developments and advances in the use of biodegradable materials for bone repair purposes. The choice between using degradable and non-degradable devices for orthopedic and maxillofacial applications must be carefully weighed. Traditional biodegradable devices for osteosynthesis have been successful in low or mild load bearing applications. However, continuing research and recent developments in the field of material science has resulted in development of biomaterials with improved strength and mechanical properties. For this purpose, biodegradable materials, including polymers, ceramics and magnesium alloys have attracted much attention for osteologic repair and applications. The next generation of biodegradable materials would benefit from recent knowledge gained regarding cell material interactions, with better control of interfacing between the material and the surrounding bone tissue. The next generations of biodegradable materials for bone repair and regeneration applications require better control of interfacing between the material and the surrounding bone tissue. Also, the mechanical properties and degradation/resorption profiles of these materials require further improvement to broaden their use and achieve better clinical results.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.