A Pimarane Diterpene and Cytotoxic Angucyclines from a Marine-Derived Micromonospora sp. in Vietnam’s East Sea

Marine Drugs

Michael W. Mullowney¹  Eoghainín Ó hAinmhire¹  Urszula Tanouye¹  Joanna E. Burdette¹  Van Cuong Pham²  Brian T. Murphy¹ 

[1] Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street (MC 781), Room 539, Chicago, IL 60612-7231, USA; E-Mails:;Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoàng Quốc Việt, Cầu Giấy, Hà Nội 10000, Vietnam; E-Mail:

关键词: actinomycete;    marine;    Micromonospora;    ovarian cancer;    Vietnam;    diterpene;   

DOI  :  10.3390/md13095815

来源: mdpi

【 摘 要 】

A screening of our actinomycete fraction library against the NCI-60 SKOV3 human tumor cell line led to the isolation of isopimara-2-one-3-ol-8,15-diene (1), lagumycin B (2), dehydrorabelomycin (3), phenanthroviridone (4), and WS-5995 A (5). These secondary metabolites were produced by a Micromonospora sp. isolated from sediment collected off the Cát Bà peninsula in the East Sea of Vietnam. Compound 1 is a novel Δ^8,9-pimarane diterpene, representing one of approximately 20 actinomycete-produced diterpenes reported to date, while compound 2 is an angucycline antibiotic that has yet to receive formal characterization. The structures of 1 and 2 were elucidated by combined NMR and MS analysis and the absolute configuration of 1 was assigned by analysis of NOESY NMR and CD spectroscopic data. Compounds 2–5 exhibited varying degrees of cytotoxicity against a panel of cancerous and non-cancerous cell lines. Overall, this study highlights our collaborative efforts to discover novel biologically active molecules from the large, underexplored, and biodiversity-rich waters of Vietnam’s East Sea.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.