Levantilides A and B, 20-Membered Macrolides from a Micromonospora Strain Isolated from the Mediterranean Deep Sea Sediment

Marine Drugs

Andrea Gärtner²  Birgit Ohlendorf²  Dirk Schulz²  Heidi Zinecker¹  Jutta Wiese² 

[1] Kieler Wirkstoff-Zentrum (KiWiZ) at the IFM-GEOMAR (Leibniz Institute of Marine Sciences), AmKiel-Kanal 44, 24106 Kiel, Germany;

关键词: macrolide;    Micromonospora;    deep sea;    natural product;    marine;   

DOI  :  10.3390/md9010098

来源: mdpi

【 摘 要 】

Two new 20-membered macrolides, levantilide A and B, were isolated from the Micromonospora strain M71-A77. Strain M71-A77 was recovered from an Eastern Mediterranean deep-sea sediment sample and revealed to produce the levantilides under in situ salinity of 38.6‰. The chemical structures of the levantilides were elucidated on the basis of different one- and two- dimensional NMR experiments. Levantilide A exhibits a moderate antiproliferative activity against several tumor cell lines.

【 授权许可】

CC BY   
© 2011 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland