The ups and downs of DNA repair biomarkers for PARP inhibitor therapies

American Journal of Cancer Research

David T Weaver¹  XiaoZhe Wang¹ 

关键词: PARP inhibitors;    cancer;    DNA repair;    biomarker;   

DOI  :  

学科分类：肿瘤学

来源: e-Century Publishing Corporation

【 摘 要 】

PARP inhibitors are emerging as a valuable new drug class in the treatment of cancer. Recent discoveries make a compelling case for the complexity of DNA repair biomarker evaluation and underscore the need to examine at multiple biomarkers in a relational manner. This review updates the current trends in DNA repair biomarker strategies in use for the PARP inhibitors and describes the impact of many DNA repair biomarkers on PARP inhibitor benefit in the cancer clinic.

【 授权许可】

Unknown