Functional Aspects of PARP1 in DNA Repair and Transcription

Biomolecules

Hui Ling Ko¹ 

[1] Singapore Immunology Network, A*STAR, 8A Biomedical Grove, #03-06 Immunos, Singapore 138648, Singapore;

关键词: ADP-ribosylation;    DNA repair;    transcription;    PARP inhibitors;    cancer;    inflammation;    oncogenic virus;   

DOI  :  10.3390/biom2040524

来源: mdpi

【 摘 要 】

Poly (ADP-ribose) polymerase 1 (PARP1) is an ADP-ribosylating enzyme essential for initiating various forms of DNA repair. Inhibiting its enzyme activity with small molecules thus achieves synthetic lethality by preventing unwanted DNA repair in the treatment of cancers. Through enzyme-dependent chromatin remodeling and enzyme-independent motif recognition, PARP1 also plays important roles in regulating gene expression. Besides presenting current findings on how each process is individually controlled by PARP1, we shall discuss how transcription and DNA repair are so intricately linked that disturbance by PARP1 enzymatic inhibition, enzyme hyperactivation in diseases, and viral replication can favor one function while suppressing the other.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.