Alzheimer's disease: diverse aspects of mitochondrial malfunctioning

International Journal of Clinical and Experimental Pathology

George Perry¹  Sónia C Correia¹  Xiongwei Zhu¹  Renato X Santos¹  Paula I Moreira¹  Xinglong Wang¹  Mark A Smith¹ 

关键词: Alzheimer's disease;    mitochondria;    mitochondrial dysfunction;    mitochondrial dynamics;   

DOI  :  

学科分类：生理学与病理学

来源: e-Century Publishing Corporation

【 摘 要 】

Alzheimer's disease is a progressive neurodegenerative disorder, either assuming a sporadic, age-associated, late-onset form, or a familial form, with early onset, in a smaller fraction of the cases. Whereas in the familial cases several mutations have been identified in genes encoding proteins related with the pathogenesis of the disease, for the sporadic form several causes have been proposed and are currently under debate. Mitochondrial dysfunction has surfaced as one of the most discussed hypotheses acting as a trigger for the pathogenesis of Alzheimer's disease. Mitochondria assume central functions in the cell, including ATP production, calcium homeostasis, reactive oxygen species generation, and apoptotic signaling. Although their role as the cause of the disease may be controversial, there is no doubt that mitochondrial dysfunction, abnormal mitochondrial dynamics and degradation by mitophagy occur during the disease process, contributing to its onset and progression.

【 授权许可】

Unknown