International Journal of Clinical and Experimental Medicine | |
Resveratrol alleviates nerve injury after cerebral ischemia and reperfusion in mice by inhibiting inflammation and apoptosis | |
Liqun Fang1  Hongmei Gao1  Yanan Wang1  Weina Zhang1  Wenjie Zhang1  | |
关键词: Resveratrol; cerebral ischemia; stroke; inflammation; apoptosis; TNF-α; | |
DOI : | |
学科分类:医学(综合) | |
来源: e-Century Publishing Corporation | |
【 摘 要 】
The role of resveratrol in cerebral ischemia/reperfusion injury is not well understood. The aim of this study was to investigate whether resveratrol modulates inflammation and oxidative stress in cerebral ischemia/reperfusion injury in mice. Rats were subjected to 2 h of transient middle cerebral artery occlusion (MCAO), followed by 24 h of reperfusion. Rats were randomly exposed to sham operation group, MCAO group and MCAO+ resveratrol group. The results demonstrated that compared to I/R, resveratrol reduced cerebral infarction area, brain water content, neuronal apoptosis, myeloperoxidase (MPO) levels, and cerebral TNF-α production. Our results suggested that resveratrol has protective effects against cerebral I/R injury in rats, which may be attributed to attenuating inflammation and apoptosis induced by cerebral ischemia reperfusion.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912140864919ZK.pdf | 845KB | download |