International Journal of Molecular Sciences | |
Endogenous Protease Nexin-1 Protects against Cerebral Ischemia | |
Osvaldo Mirante1  Melanie Price1  Wilfredo Puentes1  Ximena Castillo1  Corinne Benakis1  Jonathan Thevenet1  Denis Monard2  | |
[1] Stroke Laboratory, Neurology Service, Department of Clinical Neurosciences, Centre Hospitalier Universitaire Vaudois and Lausanne University, Lausanne 1011, Switzerland; E-Mails:;Friedrich Miescher Institute for Biomedical Research, Basel 4058, Switzerland; E-Mail: | |
关键词:
protease nexin-1;
thrombin preconditioning;
cerebral ischemia;
organotypic hippocampal slice cultures;
glucose and oxygen deprivation;
c-Jun |
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DOI : 10.3390/ijms140816719 | |
来源: mdpi | |
【 摘 要 】
The serine protease thrombin plays a role in signalling ischemic neuronal death in the brain. Paradoxically, endogenous neuroprotective mechanisms can be triggered by preconditioning with thrombin (thrombin preconditioning, TPC), leading to tolerance to cerebral ischemia. Here we studied the role of thrombin’s endogenous potent inhibitor, protease nexin-1 (PN-1), in ischemia and in tolerance to cerebral ischemia induced by TPC. Cerebral ischemia was modelled
【 授权许可】
CC BY
© 2013 by the authors; licensee MDPI, Basel, Switzerland
【 预 览 】
Files | Size | Format | View |
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RO202003190034149ZK.pdf | 382KB | download |