Melatonin-Based Therapeutics for Neuroprotection in Stroke

International Journal of Molecular Sciences

Kazutaka Shinozuka¹  Meaghan Staples¹ 

[1] Center of Excellence for Aging & Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B. Downs Blvd., Tampa, FL 33612, USA;

关键词: oxidative stress;    stroke;    neuroprotection;    cerebral ischemia;    melatonin;   

DOI  :  10.3390/ijms14058924

来源: mdpi

【 摘 要 】

The present review paper supports the approach to deliver melatonin and to target melatonin receptors for neuroprotection in stroke. We discuss laboratory evidence demonstrating neuroprotective effects of exogenous melatonin treatment and transplantation of melatonin-secreting cells in stroke. In addition, we describe a novel mechanism of action underlying the therapeutic benefits of stem cell therapy in stroke, implicating the role of melatonin receptors. As we envision the clinical entry of melatonin-based therapeutics, we discuss translational experiments that warrant consideration to reveal an optimal melatonin treatment strategy that is safe and effective for human application.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland