| Journal of Applied Biological Sciences | |
| Regulation of Yeast Life Span by Autophagy Related Genes | |
| Ahmet KOÇ1 Işıl ESMER1 Hüseyin Çağlar KARAKAY1 | |
| 关键词: Autophagy; Aging; Life Span; Yeast; Longevity; | |
| DOI : | |
| 学科分类：生物科学（综合） | |
| 来源: Nobel Bilim ve Arasirma Merkezi/Nobel Science and Research Cente | |
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【 摘 要 】
Agingcanbedefinedasagradualandprogressivedeteriorationofthehealthbythetimewhichelevatestheriskofdeath.Autophagyisaconservedpathwayfromyeasttomammals,whichisdefinedasacatabolicbulkdegradationpathway.However,inSaccharomycescerevisiae,autophagyisdefinedassinglecell’sadaptationtostarvation.Thereisanemerginglinkbetweenautophagicpathwayandlifespandetermination,howevertherolesofindividualAutophagyRelatedGenes(ATG)incellularaginghavenotbeenelucidated.Inthisstudy,weinvestigatedthereplicativeandchronologicallifespanof32yeastdeletionmutantslackingthegenesofautophagicmachinery.Weidentifiedsixmutants(atg7Δ,atg17Δ,atg27Δ,lap4Δ,atg12Δ,atg14Δ)withshorterreplicativelifespanandfourmutants(ccz1Δ,atg10Δ,atg15Δandfbp1Δ)withshorterchronologicallifespan.OurdatasuggestinvolvementofseveralnewATGmutantsinlifespandetermination.
【 授权许可】
Unknown
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201912090818739ZK.pdf | 430KB |  download |
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