Chemical and biochemical engineering quarterly | |
Microbial Production of 3-Hydroxypropionaldehyde from Glycerol Bioconversion | |
A. Zeng1  C. Ulmer1  | |
关键词: 3-Hydroxypropionaldehyde; glycerol; Klebsiella pneumoniae; biotransformation; | |
DOI : | |
来源: Croatian Society of Chemical Engineers | |
【 摘 要 】
Abstract 3-Hydroxypropionaldehyde (3-HPA) is of high industrial interest as a new platform intermediate from bioconversion of renewable materials because it can be converted into a number of large scale commodity chemicals. In this work we studied the production of 3-HPA from bioconversion of glycerol in a two-stage process. In the first stage active biomass is produced. The active biomass is then used for the production of 3-HPA in a second stage by biotransformation with the help of semicarbazide to trap 3-HPA from the culture. First we optimized the conditions for active biomass production for the biotransformation in the second step. By using a fed-batch process with proper feeding of semicarbazide and supplementary addition of active biomass we reached a final concentration of 54 g/l 3-HPA with a yield of 97 % (mol/mol). This represents the highest 3-HPA concentration and yield reported so far for the microbial production of 3-HPA from glycerol.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912090768825ZK.pdf | 1723KB | download |