Noggin Is Required for Correct Guidance of Dorsal Root Ganglion Axons

Developmental Biology

Peter M. Eimon¹  Lisa J. Brunet¹  Richard M. Harland¹  Marc S. Dionne¹ 

[1] Division of Genetics and Development, Department of Molecular and Cell Biology, University of California, Berkeley, California, 94720-3202

关键词: Noggin;    BMP;    axon guidance;   

DOI  :  10.1006/dbio.2002.0829

学科分类：生物科学（综合）

来源: Academic Press

【 摘 要 】

MembersofthebonemorphogeneticproteinfamilyofsecretedproteinsignalshavebeenimplicatedasaxonguidancecuesforspecificneuronsinCaenorhabditiselegansandinmammals.WehaveexaminedaxonalpathfindinginmicelackingthesecretedbonemorphogeneticproteinantagonistNoggin.Wehavefounddefectsinprojectionofseveralgroupsofneurons,includingtheinitialascendingprojectionsfromthedorsalrootganglia,motoraxonsinnervatingthedistalforelimb,andcranialnerveVII.Thecaseofthedorsalrootgangliondefectisespeciallyinteresting:initialprojectionsfromthedorsalrootganglionenterthedorsalrootentryzone,asnormal,butthenprojectdirectlyintothegraymatterofthespinalcord,ratherthanturningrostrallyandcaudally.Explantexperimentssuggestthatthedefectlieswithinthespinalcordandnotthedorsalrootganglionitself.However,exogenousbonemorphogeneticproteinsareunabletoattractorrepeltheseaxons,andthespinalcordshowsonlyverysubtlealterationsindorsal–ventralpatterninNogginmutants.Wesuggestthatthedefectinprojectionintothespinalcordislikelytheresultofbonemorphogeneticproteinsdisruptingthetransductionofsomeunidentifiedrepulsivesignalfromthespinalcordgraymatter.

【 授权许可】

Unknown