Prognostic value of noggin protein expression in patients with resected gastric cancer

BMC Cancer

Kwangil Yim¹  Sung-Soo Kim²  Minho Lee³  Soon Auck Hong⁴  Hye Won Hwang⁴  Su Lim Lee⁵  Eun Young Kim⁶  Hye Sung Won⁷  Sang Hoon Chun⁷  Der Sheng Sun⁷  Yoon Ho Ko⁸  Jung-Sook Yoon⁹ 

[1] Department of Hospital Pathology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea;Department of Internal Medicine, Division of Gastroenterology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea;Department of Life Science, Dongguk University-Seoul, Goyang, Republic of Korea;Department of Pathology, College of Medicine, Chung-Ang University, Seoul, Republic of Korea;Department of Radiology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea;Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea;Division of Oncology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea;Division of Oncology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea;Cancer Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea;Uijeongbu St. Mary’s Hospital Clinical Research Laboratory, The Catholic University of Korea, Seoul, Republic of Korea;

关键词: Gastric cancer;    Noggin;    RNA-binding protein for multiple splicing 2 (RBPMS2);    Prognosis;   

DOI  :  10.1186/s12885-021-08273-x

来源: Springer

【 摘 要 】

BackgroundNoggin and RNA-binding protein for multiple splicing 2 (RBPMS2) are known to regulate the expression of smooth muscle cells, endothelial cells, and osteoblasts. However, the prognostic role of combined Noggin and RBPMS2 expression in resected gastric cancer (GC) is unclear.MethodsA total of 163 patients with GC who underwent gastrectomy were included in this study. The expression of Noggin and RBPMS2 proteins in tumor cells at the tumor center and invasive front of resected GC was evaluated by immunohistochemistry, and in conjunction with clinicopathological parameters the patient survival was analyzed.ResultsRBPMS2 protein expression was high at the tumor center (n = 86, 52.8%) and low at the invasive front (n = 69, 42.3%), while Noggin protein expression was high in both tumor center (n = 91, 55.8%) and the invasive front (n = 90, 55.2%). Noggin expression at the invasive front and tumor center was significantly decreased in advanced T stage, non-intestinal-type (invasive front, P = 0.008 and P <  0.001; tumor center lesion, P = 0.013 and P = 0.001). RBPMS2 expression at the invasive front was significantly decreased in non-intestinal-type and positive lymphatic invasion (P <  0.001 and P = 0.013). Multivariate analysis revealed that high Noggin protein expression of the invasive front was an independent prognostic factor for overall survival (hazard ratio [HR], 0.58; 95% confidence interval [CI]; 0.35–0.97, P <  0.036), but not at the tumor center (HR, 1.35; 95% CI; 0.81–2.26, P = 0.251).ConclusionsOur study indicates that high Noggin expression is a crucial prognostic factor for favorable outcomes in patients with resected GC.

【 授权许可】

CC BY