Prognostic analysis of combined curative resection of the stomach and liver lesions in 30 gastric cancer patients with synchronous liver metastases

BMC Surgery

Xin-Yu Qin¹  Yi-Hong Sun¹  Jing Qin¹  Xue-Fei Wang¹  Ying-Yong Hou²  Xiao-Dong Gao¹  Jia-Qian Ling¹  Kun-Tang Shen¹  Yan-Na Wang¹ 

[1] Department of General Surgery, Zhongshan Hospital of Fudan University, No 180 Fenglin Road, Shanghai, 200032, China;Department of Pathology, Zhongshan Hospital of Fudan University, No 180 Fenglin Road, Shanghai, 200032, China

关键词: Prognosis;    Clinicopathological factors;    Liver metastases;    Gastric cancer;   

Others  :  1123362
DOI  :  10.1186/1471-2482-12-20

 received in 2012-06-10, accepted in 2012-10-09,  发布年份 2012

【 摘 要 】

Background

Gastric cancer with synchronous liver metastasis remains a clinical treatment challenge. There has been a longstanding debate on the question whether surgical resection could be beneficial to long-term survival. This study is to investigate the effectiveness and prognostic factors of combined curative resection of the stomach and liver lesions in gastric cancer patients with synchronous liver metastases.

Methods

A total of 30 patients who underwent simultaneous curative gastric and liver resection from March 2003 to April 2008 were analyzed retrospectively. Univariate and multivariate analyses were performed to select independent factors for survival.

Results

The overall 1-, 2-, 3- and 5-year survival rates of 30 patients were 43.3%, 30.0%, 16.7% and 16.7%, respectively, with a median survival of 11.0 months and 5 patients still living by the time of last follow-up. Single liver metastasis (p = 0.028) and an absence of peritoneal dissemination (p = 0.007) were significantly independent prognostic factors for these gastric cancer patients with synchronous liver metastases. Major adverse events were protracted stomach paralysis in 2 patients and pulmonary infection in another 2 patients, all of whom recovered after conservative treatment.

Conclusions

This descriptive study without control group found that patients with solitary liver metastasis and absence of peritoneal dissemination could have better survival benefit from simultaneous curative resection of the gastric cancer and liver metastases.

【 授权许可】

   
2012 Wang et al.; licensee BioMed Central Ltd.

【 图 表 】

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