Oligodendrocyte Precursor Cells from Different Brain Regions Express Divergent Properties Consistent with the Differing Time Courses of Myelination in These Regions

Developmental Biology

Joel Smith¹  Margot Mayer-Pröschel¹  Jennifer Power¹  Mark Noble¹ 

[1] Columbia University, Center for Neurobiology and Behavior, New York, New York, 10032

关键词: myelination;    development;    oligodendrocyte-type-2 astrocyte progenitor;    oligodendrocyte precursor cell;    oligodendrocyte;    self-renewal;    precursor cell;   

DOI  :  10.1006/dbio.2002.0610

学科分类：生物科学（综合）

来源: Academic Press

【 摘 要 】

DifferentCNSregionsexhibitdifferenttemporalpatternsofoligodendrocytegenerationandmyelinogenesis.Characterizationofoligodendrocyte-type-2astrocyteprogenitorcells(hereabbreviatedasO-2A/OPCs)isolatedfromdifferentregionsindicatesthesedevelopmentalpatternsareconsistentwithpropertiesofthespecificO-2A/OPCsresidentineachregion.Markeddifferenceswereseeninself-renewalanddifferentiationcharacteristicsofO-2A/OPCsisolatedfromcortex,opticnerveandopticchiasm.Inconditionswhereopticnerve-derivedO-2A/OPCsgeneratedoligodendrocyteswithin2days,oligodendrocytesarosefromchiasm-derivedcellsafter5daysandfromcorticalO-2A/OPCsonlyafter7–10days.Thesedifferences,whichappeartobecell-intrinsic(andmayberelatedtointracellularredoxstate),weremanifestedbothinreducedpercentagesofclonesproducingoligodendrocytesandinalesserrepresentationofoligodendrocytesinindividualclones.Inaddition,responsivenessofopticnerve-,chiasm-andcortex-derivedO-2A/OPCstothyroidhormone(TH)andciliaryneurotrophicfactor(CNTF),well-characterizedinducersofoligodendrocytegeneration,wasinverselyrelatedtotheextentofself-renewalobservedinbasaldivisionconditions.Ourresultsdemonstratehithertounrecognizedcomplexitiesamongtheprecursorcellsthoughttobetheimmediateancestorsofoligodendrocytes,andsuggestthatthepropertiesofthesedifferentpopulationsmaycontributetothediversetimecoursesofmyelinationindifferentCNSregions.

【 授权许可】

Unknown