Beneficial Effect of α-Tocopherol in Renal Ischemia-Reperfusion in Rats

The Japanese Journal of Pharmacology

Cláudio Telöken³  Luiz Pereira-Lima¹  Ernani Luís Rhoden¹  Márcio Luís Lucas²  Adriane Belló-Klein⁴  Cláudia Ramos Rhoden² 

[1] Post-Graduation Course in Medical Clinical, Federal University of Rio Grande do Sul/Porto Alegre Clinical Hospital; and Post-Graduation Course of School of Medical Sciences/Santa Casa University Hospital;Department of Pharmacology, Porto Alegre School of Medical Sciences/Santa Casa University Hospital;Department of Surgery, Porto Alegre School of Medical Sciences/Santa Casa University Hospital;Laboratory of Physiology, Federal University of Rio Grande do Sul

关键词: α-Tocopherol;    Renal ischemia-reperfusion;    Lipid peroxidation;   

DOI  :  10.1254/jjp.87.164

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(12)Cited-By(11)We evaluated the effects of α-tocopherol (vitamin E) on the products of lipid peroxidation and serum creatinine levels in a rat model of renal ischemia-reperfusion. The animals were submitted to sham operation or renal ischemia-reperfusion, and they were pretreated with α-tocopherol or the vehicle saline. In four groups, we analyzed the lipid peroxidation products by measuring malondialdehyde and chemiluminescence levels. In the other three groups, we studied the serum creatinine levels after the procedures. In our study, the pretreatment with α-tocopherol reduced significantly the lipid peroxidation of renal cells and renal dysfunction induced by renal ischemia-reperfusion in rats.

【 授权许可】

Unknown