Effect of Gosha-jinki-gan, a Kampo Medicine, on Enhanced Platelet Aggregation in Streptozotocin-Induced Diabetic Rats

The Japanese Journal of Pharmacology

Yasuhiro Komatsu¹  Junzo Kamei²  Yasuyuki Suzuki¹  Kazuhiro Goto¹  Atsushi Ishige¹ 

[1] Kampo and Pharmacognosy Laboratories, Tsumura & Co.;Department of Pathophysiology & Therapeutics, Faculty of Pharmaceutical Sciences, Hoshi University

关键词: Gosha-jinki-gan;    Platelet aggregation;    Nitric oxide;   

DOI  :  10.1254/jjp.78.87

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(12)Cited-By(12)We evaluated the effects of Gosha-jinki-gan on platelet aggregation in streptozotocin-induced diabetic rats. Enhanced ADP (2 μM)-induced aggregation of platelets obtained from diabetic rats was inhibited by a single treatment with Gosha-jinki-gan (0.3, 1.5 g/kg, p.o.). The anti-platelet aggregatory effect of Gosha-jinki-gan (1.5 g/kg, p.o.) was attenuated by simultaneous administration of atropine (1 mg/kg, i.p.) and was abolished by combination of atropine with Hoe 140 (250 μg/kg×2, i.p.), a bradykinin B2 receptor antagonist or L-NAME (10 mg/kg, i.p.), an inhibitor of nitric oxide-synthase. These results suggested that Gosha-jinki-gan could improve platelet aggregation in diabetes through increased production of nitric oxide via bradykinin B2-receptors and muscarinic acetylcholine receptors.

【 授权许可】

Unknown