Antinociceptive Mechanism of Gosha-jinki-gan in StreptozotocinInduced Diabetic Animals: Role of Nitric Oxide in the Periphery

The Japanese Journal of Pharmacology

Yasuhiro Komatsu¹  Junzo Kamei²  Yasuyuki Suzuki¹  Kazuhiro Goto¹  Atsushi Ishige¹ 

[1] Kampo and Pharmacognosy Laboratories, Tsumura & Co.;Department of Pathophysiology & Therapeutics, Faculty of Pharmaceutical Sciences, Hoshi University

关键词: Gosha-jinki-gan;    Antinociception;    Nitric oxide;   

DOI  :  10.1254/jjp.79.387

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)Cited-By(24)Using streptozotocin-induced diabetic mice and rats, we evaluated the antinociceptive mechanism of Gosha-jinki-gan. The antinociceptive effect of Gosha-jinki-gan (0.3 g/kg, p.o.) in diabetic mice, as determined by the tail-pressure test, was inhibited by NG-nitro-L-arginine methyl ester (L-NAME; 2, 5 mg/kg, i.p.). When L-NAME (10 μg) or methylene blue (500 μg) was topically administered to the intraplantar area of the hind paw, the region used for the paw-pressure test, the antinociceptive activity of Gosha-jinki-gan (0.3 g/kg, p.o.) in diabetic rats was decreased. These results suggested that the antinociceptive effect of Gosha-jinki-gan partly resulted from the peripheral action of increasingly produced nitric oxide.

【 授权许可】

Unknown