Continuous Infusion of β-Amyloid Protein into the Rat Cerebral Ventricle Induces Learning Impairment and Neuronal and Morphological Degeneration

The Japanese Journal of Pharmacology

Atsumi Nitta¹  Takaaki Hasegawa¹  Taneo Fukuta¹  Toshitaka Nabeshima¹ 

[1] Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University School of Medicine

关键词: Amyloid protein;    Alzheimer's disease;    Learning and memory;    Cholinergic neuron;    lial fibrillary acidic protein;   

DOI  :  10.1254/jjp.73.51

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(19)Cited-By(87)To investigate the toxicity of β-amyloid protein, a component of the senile plaques in Alzheimer''s disease, it was infused into the cerebral ventricle of rats for 14 days by a mini-osmotic pump. Performances in the water maze and passive avoidance tasks in β-amyloid protein-treated rats were impaired. Choline acetyltransferase activity significantly decreased in the hippocampus both immediately and 2 weeks after the cessation of the infusion. However, the learning impairment was recoverable 2 weeks after cessation of the infusion. Both immediately and 2 weeks after the cessation of the infusion, glial fibrillary acidic protein immunoreactivity increased. Furthermore, β-amyloid protein altered the staining in the nuclei of hippocampal cells for only 2 weeks after the cessation. These results suggest that β-amyloid protein produces some damage in the central nervous system in vivo.

【 授权许可】

Unknown